Hollande Fixative - GI Pathology Applications

Balanced formalin 20%, acetic 5%, alcohol 80% maintains neuroendocrine granules across pancreatic NET and carcinoid tumor diagnosis.

Endocrine pathology preserves zymogen granules confirming acinar cell carcinoma. Superior cytoplasmic fixation prevents crush artifact misdiagnosis.

Quality control confirms component balance, tissue penetration, and 12-month stability. Alcohol component prevents autolysis artifacts.