Sodium Citrate 38% - Coagulation Applications
38% trisodium citrate solution delivers precise calcium chelation supporting coagulation testing, transfusion medicine, and platelet research applications across clinical laboratories.Coagulation laboratories employ 1:9 citrate:blood ratio anticoagulating samples for PT, aPTT, fibrinogen, and D-dimer assays. Standardized chelation prevents clot formation while maintaining factor activities essential for thrombophilia screening.Blood banking facilities utilize citrate anticoagulation preserving platelet viability during apheresis collection and storage. CPD/triglyceride formulations extend shelf life supporting transfusion support for massive hemorrhage protocols.Hematology laboratories standardize citrate concentration ensuring reproducible platelet aggregation responses. ADP, collagen, and ristocetin-induced aggregation patterns guide diagnosis of von Willebrand disease and Glanzmann thrombasthenia.Research laboratories investigate calcium-dependent signaling pathways using citrate reversal protocols. MgCl2 recalcification restores coagulation cascade activation supporting kinetic studies of novel anticoagulant development.Quality control programs verify citrate concentration (titration), pH specifications (5.0-7.0), and endotoxin absence. Piperazine stabilization prevents calcium precipitation compromising anticoagulant performance specifications.Transfer pipettes enable precise 1:9 dilution preventing under/over-citration artifacts. Secondary pouches maintain sterility during multi-dose dispensing supporting workflow efficiency across laboratory sections.Safety protocols mandate gloves preventing dermal irritation. Spill neutralization with calcium chloride prevents slippery surfaces compromising personnel safety during laboratory operations.ISO 13485 manufacturing confirms citrate content accuracy, sterility assurance, and pyrogen-free specifications. CLSI/ISP/NCQA compliance supports coagulation laboratory accreditation across clinical service environments.
